Alan Dombkowski, Ph.D.
Department of Pediatrics
Department of Oncology
School of Medicine
Wayne State University
Children’s Hospital of Michigan
3901 Beaubien Blvd. Room 3N47
Detroit, MI 48201
Laboratory of Functional Genomics and Bioinformatics
The central theme of our research is integration of functional genomics with computational methods to uncover molecular mechanisms of disease and identify potential therapeutic targets. We are focused on characterization of cellular pathways and signaling events involved in disease progression and pathology. Towards that goal, we develop and apply computational methods to leverage the depth and dimensionality of "omics" data derived from a range of molecular levels, including transcript, microRNA, methylation, and protein. Our ongoing projects include identification of epigenetic events associated with epilepsy in pediatric patients with tuberous sclerosis complex (TSC).
Epilepsy and Tuberous Sclerosis Complex (TSC)
We are uncovering molecular events associated with the onset of epilepsy in children with tuberous sclerosis complex.
We have developed bioinformatics tools that are used by labs throughout the world, as well as licensed by pharmaceutical firms.
Our laboratory uses genomics technology to detect genetic changes and cellular events associated with disease onset and progression.